Comparing the effect of Dexmedetomidine and Fentanyl in change of hemodynamic response and block characters after spinal anesthesia with Ropivacaeen in lower limb fracture

Comparison of Dexmedetomidine and Fentanyl effect in change of hemodynamic response and block characters after spinal anesthesia with Ropivacaeen in lower limb fracture

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141209020258N115

Enrollment

Registered

2019-07-07

Start date

2019-04-21

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Femure fracture. Fracture of neck of femur

Interventions

Intervention 1: Intervention group1: We inject 5 microgram Dexmedetomidine plus 3-4 milliliter Ropivacaeen(15-20 milligram)(Hospira Co.America). Intervention 2: Intervention group2: We inject 20 micro

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: ASA class 1 and 2 Patients undergoing femoral orthopedic surgery Lack of failure to perform spinal anesthesia No history of taking beta-blockers and alpha-2 calcium channel blockers and blockers Lack of cardiovascular problems No pregnancy Absence of coagulation disorders Non-localized infection in the spinal cord Absence of mental and psychological problems Lack of peripheral and central neuropathy

Exclusion criteria

Exclusion criteria: Patient dissatisfaction Blocks failed Surgical operations more than 120 minutes Patients who have heart-respiratory arrhythmia during operation

Design outcomes

Primary

Measure	Time frame
Mean arterial blood pressure. Timepoint: In the first 15 minutes every 5 minutes, then at minutes 30, 60, 45, 90. Method of measurement: Barometer.;Heart rate. Timepoint: In the first 15 minutes every 5 minutes, then at minutes 30, 60, 45, 90. Method of measurement: Count.;Percent of oxygen saturation. Timepoint: In the first 15 minutes every 5 minutes, then at minutes 30, 60, 45, 90. Method of measurement: Pulse oximetry.;Duration of motor block. Timepoint: Every 5 minute. Method of measurement: Minute.;Duration of Sensory block. Timepoint: Every 5 minutes. Method of measurement: Minute.;Pain. Timepoint: At recovery and 2 and 4 and 8 postoperative. Method of measurement: Visual Analogue Scale Questionnaire.;Mean of narcotic. Timepoint: 24 hour after surgery. Method of measurement: Milligram.	—

Measure

Time frame

Mean arterial blood pressure. Timepoint: In the first 15 minutes every 5 minutes, then at minutes 30, 60, 45, 90. Method of measurement: Barometer.;Heart rate. Timepoint: In the first 15 minutes every 5 minutes, then at minutes 30, 60, 45, 90. Method of measurement: Count.;Percent of oxygen saturation. Timepoint: In the first 15 minutes every 5 minutes, then at minutes 30, 60, 45, 90. Method of measurement: Pulse oximetry.;Duration of motor block. Timepoint: Every 5 minute. Method of measurement: Minute.;Duration of Sensory block. Timepoint: Every 5 minutes. Method of measurement: Minute.;Pain. Timepoint: At recovery and 2 and 4 and 8 postoperative. Method of measurement: Visual Analogue Scale Questionnaire.;Mean of narcotic. Timepoint: 24 hour after surgery. Method of measurement: Milligram.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Shirin Pazuki

Arak University of Medical Sciences

pazuki@arakmu.ac.ir+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026