The effect of drug anesthesia on pain and hemodynamic changes during intravenous regional anesthesia of distal radius surgery

Comparison of the Effect of Adding Dexmedetomidine, Ketamine, Neostigmine and Magnesium Sulfate to Rupivacaine inmanagment of pain and Hemodynamic Changes in intravenous regional anesthesia of distal radius surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141209020258N113

Enrollment

150

Registered

2019-06-12

Start date

2019-03-06

Completion date

Unknown

Last updated

2019-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Forearm surgery. Fracture of forearm, part unspecified

Interventions

Intervention 1: Intervention group 1: We will inject 0.5 micro gram in kilogram Dexmedetomidine ( Exir.co .Iran) plus Rupivacaine 0.2 (Molteni .Co.Italia) in first group. Intervention 2: Interventio

Eligibility

Sex/Gender

All

Age

20 Years to 65 Years

Inclusion criteria

Inclusion criteria: candidate for forearm Surgery ASA class I and II Being at the age of 20-65 years old

Exclusion criteria

Exclusion criteria: Duration of surgery less than 30 minutes and more than 90 minutes localized intravenous anesthetics termination during surgery for any reason Reinoids disease Sickle cell anemia history of allergy to drugs using drugs and psychotropic substances There is more than a fracture in the body or surgery

Design outcomes

Primary

Measure	Time frame
Mean arterial blood pressure. Timepoint: Before starting tourniquet, 5, 10, 15, 20, 30, 40 minutes after start of surgery, and then every 10 minutes after emptying the tourniquet and recovery. Method of measurement: Barometer.;Heart rate. Timepoint: Before starting tourniquet, 5, 10, 15, 20, 30, 40 minutes after start of surgery, and then every 10 minutes after emptying the tourniquet and recovery. Method of measurement: Count.;Percent of oxygen saturation. Timepoint: Before starting tourniquet, 5, 10, 15, 20, 30, 40 minutes after start of surgery, and then every 10 minutes after emptying the tourniquet and recovery. Method of measurement: Pulse oximetry.;Duration of motor block. Timepoint: Every 5 minute. Method of measurement: Minute.;Duration of Sensory block. Timepoint: Every 1minute. Method of measurement: Minute.;Pain. Timepoint: After filling the tourniquet, at the time of 15, 30 and 45 and every 15 minutes to end of surgery. Method of measurement: Visual Analogue Scale Questionnaire.;Mean of narcotic. Timepoint: 24 hour after surgery. Method of measurement: Milligram.	—

Measure

Time frame

Mean arterial blood pressure. Timepoint: Before starting tourniquet, 5, 10, 15, 20, 30, 40 minutes after start of surgery, and then every 10 minutes after emptying the tourniquet and recovery. Method of measurement: Barometer.;Heart rate. Timepoint: Before starting tourniquet, 5, 10, 15, 20, 30, 40 minutes after start of surgery, and then every 10 minutes after emptying the tourniquet and recovery. Method of measurement: Count.;Percent of oxygen saturation. Timepoint: Before starting tourniquet, 5, 10, 15, 20, 30, 40 minutes after start of surgery, and then every 10 minutes after emptying the tourniquet and recovery. Method of measurement: Pulse oximetry.;Duration of motor block. Timepoint: Every 5 minute. Method of measurement: Minute.;Duration of Sensory block. Timepoint: Every 1minute. Method of measurement: Minute.;Pain. Timepoint: After filling the tourniquet, at the time of 15, 30 and 45 and every 15 minutes to end of surgery. Method of measurement: Visual Analogue Scale Questionnaire.;Mean of narcotic. Timepoint: 24 hour after surgery. Method of measurement: Milligram.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Esmaeel Moshiri

Arak University of Medical Sciences

modir.he@gmail.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 19, 2026