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Intralesional methotrexate injection in alopecia areata

Evaluation of the efficacy and side effects of intralesional methotrexate injection in comparison with intralesional triamcinolone acetonide in patients with alopecia areata in patients referred to Razi Hospital in 2021-2022

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20141209020250N6
Enrollment
40
Registered
2023-05-29
Start date
2023-01-30
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alopecia Areata.

Interventions

Intervention 1: Intervention group: a vial of methotrexate containing 25 mg/ml is used. After septic procedures, methotrexate is injected intradermally in the lesion itself and one centimeter around i

Sponsors

Vice chancellor of Research and Technology,Tehran University of Medical Sciences and Health Services
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to 60 Years

Inclusion criteria

Inclusion criteria: Adult patients (aged 16-60 years) Patients with alopecia areata who have less than 20% involvement of the scalp have not received any treatment for AA in the past 1 month.

Exclusion criteria

Exclusion criteria: Children and patients under 16 years, pregnant and lactating women, chronic patients including patients with liver or blood disorders, patients with immunodeficiency, infectious disease patients with diffuse types (alopecia totalis, alopecia universalis and more than 20%) and positive pull tests that are candidates for systemic treatment patients who were treated for alopecia areata during the previous month

Design outcomes

Primary

MeasureTime frame
Alopecia Areata severity index. Timepoint: The beginning of the study, one month, two months, three months, six months after the start of the study. Method of measurement: Viewing Dermoscopy criteria.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNarges Ghandi

Tehran University of Medical Sciences

nghandi@tums.ac.ir+98 21 5561 8989

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026