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The effect of letrozole and methformin on endometrial histology in patients with disordered proliferative endometrium and simple hyperplasia utreus cancer.

Comparative effectiveness of letrozole and methformin on endometrial histology in patients with disordered proliferative endometrium and simple hyperplasia utreus cancer in alzahra hospital.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT201412085563N6
Enrollment
90
Registered
2015-01-03
Start date
2014-12-14
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with abnormal bleeding and endometrial proliferative and Hayprplastyk with irregular glands. Endometrial glandular hyperplasia

Interventions

Intervention 1: In the third group with cervical cancer:Drug letrozole (made in Iran, Iran Hormone) 2.5 mg BID and 500 mg BID Metformin is prescribed for three months. Intervention 2: Group II endomet
Treatment - Drugs
In the third group with cervical cancer:Drug letrozole (made in Iran, Iran Hormone) 2.5 mg BID and 500 mg BID Metformin is prescribed for three months.
Group II endometrial proliferative effect:Drug letrozole (made in Iran, Iran Hormone) 2.5 mg BID and 500 mg BID Metformin is prescribed for three months.
The first group with abnormal uterine bleeding: Drug letrozole (made in Iran, Iran Hormone) 2.5 mg BID and 500 mg BID Metformin is prescribed for three months.

Sponsors

Vice chancellor for Research,Tabriz University Of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients with abnormal uterine bleeding and havingdisordered proliferative or hyperplastic endometrium and uterine cancer;Consent to participate Exclusion criteria:People who are allergic to metformin and letrozole, severe impairment of hepatic function; Uncontrolled high blood pressure; Thromboembolism

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Histologic types of endometrial. Timepoint: Three months after the first dose. Method of measurement: Microscopic examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Elaheh Ouladsahebmadarek

Tabriz University Of Medical Sciences

wrhrcenter@gmail.com; lahroudin@gmail.com+98 41 3553 9161

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026