The effect of L-carnitine supplementation on oxidative stress indices and clinical outcomes in burn patients.

The effect of L-carnitine supplementation on oxidative stress indices and clinical outcomes in patients hospitalized in the burn intensive care unit

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141208020249N11

Enrollment

Registered

2026-04-12

Start date

2026-02-08

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Burn. Condition 2: Burn. Condition 3: Burn. Condition 4: Burn. Condition 5: Burn. Condition 6: Burn. Condition 7: Burn. Condition 8: Burn. Burn and corrosion of head, face, and neck Burn and corrosion of trunk Burn and corrosion of shoulder and upper limb, except wrist and hand Burn and corrosion of wrist and hand Burn and corrosion of lower limb, except ankle and foot Burn and corrosion of ankle and foot Burn and corrosion confined to eye and adnexa Burn and corrosion of re

Interventions

Intervention 1: Intervention group: Taking L-carnitine supplements by gavage at a daily dose of 3 grams (one gram every 8 hours). Intervention 2: Control group: Receive standard treatments including f

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Burns of at least one percent of the total body surface area (TBSA=1%)

Exclusion criteria

Exclusion criteria: Non-cooperation or lack of consent to participate in the study any contraindications to taking L-carnitine

Design outcomes

Primary

Measure	Time frame
Oxidative stress indicators include Catalase, Glutathione (GSH), Malondialdehyde (MDA), Total Antioxidant Capacity (TAC), Total Oxidant Status (TOS), Glutathione Peroxidase (GPx), and Superoxide Dismutase (SOD). Timepoint: At the time of patient arrival and on the seventh day after the intervention. Method of measurement: test kits.;Clinical outcomes include length of stay, wound healing, skin graft success, and incidence of adverse events. Timepoint: Day of discharge or death of the patient. Method of measurement: Patient visit and file review.	—

Measure

Time frame

Oxidative stress indicators include Catalase, Glutathione (GSH), Malondialdehyde (MDA), Total Antioxidant Capacity (TAC), Total Oxidant Status (TOS), Glutathione Peroxidase (GPx), and Superoxide Dismutase (SOD). Timepoint: At the time of patient arrival and on the seventh day after the intervention. Method of measurement: test kits.;Clinical outcomes include length of stay, wound healing, skin graft success, and incidence of adverse events. Timepoint: Day of discharge or death of the patient. Method of measurement: Patient visit and file review.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAhmad Ghaderi

Sanandaj University of Medical Sciences

ahmadqaderi392@gmail.com+98 87 3361 1320

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026