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Effect of phenylephrine and ephedrine for treatment of hypotension during Caesarean

Comparison between the effect of Phenylephrine versus Ephedrine on treatment of maternal hypotension & neonatal cord Venus blood analysis during caesarean section under spinal anesthesia with Bupivacaine

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT201412046280N5
Enrollment
100
Registered
2014-12-17
Start date
2015-01-20
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Maternal hypotension. Maternal hypotension

Interventions

Intervention 1: Intervention1: Injection 100 micro ggram phenylephrine if hypotension is more than 20% from baseline or a systolic blood pressure less than 100. Intervention 2: Intervention 2: Injecti
Treatment - Drugs
Intervention1: Injection 100 micro ggram phenylephrine if hypotension is more than 20% from baseline or a systolic blood pressure less than 100
Intervention 2: Injection 10 mg ephedrine if hypotension is more than 20% from baseline or a systolic blood pressure less than 100

Sponsors

Vice Chancellor for research of Guilan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age 18-40 years; MOM height 150-170 cm; Weight 60-90 kg; Gestational age 37-42 weeks; Singleton; ASA class 1, 2; Systolic blood pressure under 100 mmHg after spinal anesthesia Exclusion criteria: Severe respiratory distress; Cord prolapse; Decollement; Placenta prevail

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Blood pressure. Timepoint: After spinal anesthesia, then every 5 minutes until 30 minutes and every 10 minutes until reduced sensation below the level of T10. Method of measurement: mmHg by Saadat monitoring system.;Oxygen saturation. Timepoint: Upon arrival to operating room , 3, 5, 10, 15 minutes after endotracheal intubatioin and 10 minutes after extubation. Method of measurement: Percent by pulse oximeter.;PH umblical vein. Timepoint: After birth. Method of measurement: by AVL.;Neonate APgar. Timepoint: First and five minutes after birth. Method of measurement: Apgar score.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Haghighi

Guilan University of Medical Sciences

arcguilan1392@gmail.com+98 13 3331 0434

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026