Relation between Pragabalin using and post oprative pain after Laparascopic Hystrectomy.
Conditions
Interventions
Placebo
Intervention 1: Administration of 75 mg pregabalin, night before and 30 min before and 6 hours after surgery. Intervention 2: Administration of 150 mg pregabalin, night before and 30 min before and 6
Treatment - Drugs
Administration of 75 mg pregabalin, night before and 30 min before and 6 hours after surgery
Administration of 150 mg pregabalin, night before and 30 min before and 6 hours after surgery
Administration of 300 mg pregabalin, night before and 30 min before and 6 hours after surgery
Administration of placebo, night before and 30 min before and 6 hours after surgery
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients with elective laparoscopic hysterectomy with ASA physical status I-II; without chronic pelvic pain and long-analgesics consumption. Exclusion criteria: patients with history of the chronic pain or daily consumption of analgesics types; have uncontrolled underlying disease (diabetes, hypertension); renal or hepatic failure; suffering from mental illness; major depression or bi-polar; with a history of alcohol or drug abuse; sensitivity to study medication.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post Oprative Pain. Timepoint: Assay of pain at 0, 2, 4, 6, 8, 12 and 24 hours after surgery. Method of measurement: Visual Analog Score (VAS) Form of pain.;Pethedine Consumption. Timepoint: First 24 hours after surgery. Method of measurement: Pethidin consumption doses.;Nausea and Vomiting. Timepoint: First 24 hours after surgery. Method of measurement: Antiemetic doses.;Sedation Score. Timepoint: First 24 hours after surgery. Method of measurement: Examination and observation of the patient. | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of Anaesthesia. Timepoint: From induction of anesthesia time to extubation. Method of measurement: Time observation.;Recovery Duration. Timepoint: From extubation to transfer to the ward. Method of measurement: Time observation.;Patient Satisfaction. Timepoint: First 24 hours after surgery. Method of measurement: Questionnarie.;Pregabalin Side Effects. Timepoint: First 24 hours after surgery. Method of measurement: Examination and observation of the patient. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSafoura Rouholamin
Isfahan University of Medical Sciences
Outcome results
None listed