Effects of normal salin infusion on pregnancy rate

Investigation of intrauterine saline infusion at day 3 to 5 of ovarian stimulation on the clinical outcome of Intracytoplasmic sperm injection- embryo transfer cycles in patients with repeated implantation failure.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014120219426N3

Enrollment

Registered

2014-12-07

Start date

2014-04-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Noninflammatory disorders of female genital tract. Complications associated with artificial fertilization

Interventions

Intervention 1: Intervention: on days 3 to 5 of the stimulation cycles randomly injecting 20 mL of saline by IUI catheters in to the intrauterine cavity with ultrasound guidance and then suctioned out

Treatment - Other

Intervention: on days 3 to 5 of the stimulation cycles randomly injecting 20 mL of saline by IUI catheters in to the intrauterine cavity with ultrasound guidance and then suctioned out.

Control: Stimulation cycles continued without any intervention

Eligibility

Sex/Gender

Female

Age

20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: women aged 20-45 years old, undergoing ICSI-ET or freeze embryo transfer; normal hysterosalpingography or hysteroscopy; at least 2 previous failed intracytoplasmic sperm injection-embryo transfer cycles despite transfer of good quality embryos. Exclusion criteria: abnormal uterine cavity in hysterosalpingography or hysteroscopy; poor responders in previous hormonal stimulation cycles (less than 4 follicles with a size greater than 14 mm on the day of Human chorionic gonadothropin injection).

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Clinical pregnancy. Timepoint: Four weeks after embryo trsnsfer. Method of measurement: Vaginal ultrasonography.	—

Secondary

Measure	Time frame
Chemical pregnancy. Timepoint: Two weeks after embryo transfer. Method of measurement: B HCG kit.;Ongoing pregnancy. Timepoint: Ten weeks after embryo transfer. Method of measurement: Transabdominal ultrasonography.;Miscariage rate. Timepoint: 22 weeks after embryo transfer. Method of measurement: History, Ultrasonography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaghar Salehpour

Infertility & Reproductive Health Research Center Shahid Beheshti University of Medical Science

saghar.salehpour@yahoo.com+98 21 2243 2558

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026