Acute Gastrointestinal hemorrhage. Gastrointestinal haemorrhage, unspecified
Conditions
Interventions
Intervention 1: Group A :tranexamic acid 1 g slow and diluted IV injection q6h for 24hours.Group B:tranexamic acid 1 g slow and diluted IV injection q6h for 24hours plus topical -single dose tranexam
Treatment - Drugs
Group A :tranexamic acid 1 g slow and diluted IV injection q6h for 24hours.Group B:tranexamic acid 1 g slow and diluted IV injection q6h for 24hours plus topical -single dose tranexamic acid 1 g in
Group B:tranexamic acid 1 g slow and diluted IV injection q6h for 24hours plus topical -single dose tranexamic acid 1 g in 500 normal sailin by NG rout with NG clamp for 30 minute and then NG set free
Group C:normal sailin as the placebo same as the two mentioned above rout
Sponsors
Colorectal Research Center,Rasoul Akram Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion Criteria:Chief complaint of hematemesis, melena or hematochezia and objective signs of gastrointestinal bleeding,and age more than 18 Exclusion Criteria:Pregnancy , lactation,Oral Contraceotive Pill users,History of thromboembolic disease(cardiac and/or cerebrovascular thrombotic events,pulmonary thromboembolc eventi,deep vein thrombosis),Malignancy (except those cured and has not recurred more than two years), End stage renal disease and /or Nephrotic syndrome, Underlying cardiac rhythm disorder where anticoagulation is indicated (e.g. atrial fibrillation/flutter),Signs and symptoms suggestive of clinically significant infectious disease (e.g. body temperature > 38 degree),Acquired color vision impairment, visual loss and retinal venous and arterial occlusions,Past history of seizure ,severe liver disease and/or previous history of variceal bleeding,Cases where informed consent is unobtainable, any allergic history to this medication
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urgent endosopy rate. Timepoint: ;first endoscopy at less than 24hour after emergency visit. Method of measurement: Time frame as hour. | — |
Secondary
| Measure | Time frame |
|---|---|
| Endoscopic detection rate in early endoscopy. Timepoint: First 24 hours. Method of measurement: Report of early endoscopy.;Blood transfusion rate. Timepoint: First 24 and 72 hours and first 1 months after bleeding. Method of measurement: Number of Pack Cell.;Endoscopic intervention rate in early endoscopy. Timepoint: Early endoscopy in first 24 hours. Method of measurement: Report of early endoscopy.;Rebleeding rate. Timepoint: First 24 and 72 hours and first 1 months after bleeding. Method of measurement: Data gathering sheet.;Surgical intervention rate. Timepoint: First 24 and 72 hours and first 1 months after bleeding. Method of measurement: Data gathering sheet.;ICU admission rate. Timepoint: First 24 and 72 hours and first 1 months after bleeding. Method of measurement: Data gathering sheet.;Mortality rate. Timepoint: First 24 and 72 hours and first 1 months after bleeding. Method of measurement: Data gathering sheet.;Endoscopic time in early endoscopy. Timepoint: Early endoscopic time in first 24 hours. Method of measurement: Time frame in minute. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Saadegh Ghafoori
Colorectal Research Center, Rasoul Akram Hospital
Outcome results
None listed