Gastroesophageal reflux disease (GERD). Gastro-oesophageal reflux disease without oesophagitis
Conditions
Interventions
Intervention 1: In the intervention branch of the study, subjects are given 10 grams quince paste after meal for 4 weeks. Intervention 2: In the control branch, subjects are given 150 mg ranitidine/tw
Treatment - Other
Treatment - Drugs
In the intervention branch of the study, subjects are given 10 grams quince paste after meal for 4 weeks.
In the control branch, subjects are given 150 mg ranitidine/twice a day for 4 weeks.
Sponsors
College of Traditional Medicine of Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1) Pregnant patients aged 18 to 35 years old. 2) Gestational age 12 to 34 weeks. 3) Not responsiveness to 2-week lifestyle modification. 4) Not taking any drug for the complains in the leading week to the study. 5) Giving informed consent. 6) Secured follow-up. Exclusion criteria: 1) Unbearable heartburn sensation. 2) Previously Approved GERD leading to pregnancy, such as peptic ulcer, duodenal ulcer, IBS, and so on. 3) High-risk pregnancies. 4) Pregnancy complications, such as AUB, threatened abortion, etc. 5) History of drug abuse, alcohol and smoking. 6) History of chronic diseases. 7) History of infertility. 8) Assisted reproductive technology pregnancy. 9) History of respiratory diseases. 10) History of allergic reaction to quince products.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of regurgitation. Timepoint: Before intervention, 2 and 4 weeks after commencement, at the end of intervention. Method of measurement: Myoclinic questionnaire.;Severity of epigastric pain. Timepoint: Before intervention, 2 and 4 weeks after commencement, at the end of intervention. Method of measurement: Myoclinic questionnaire.;Frequency of regurgitation. Timepoint: Before intervention, 2 and 4 weeks after commencement, at the end of intervention. Method of measurement: Myoclinic questionnaire.;Frequency of heartburn. Timepoint: Before intervention, 2 and 4 weeks after commencement, at the end of intervention. Method of measurement: Myoclinic questionnaire.;Severity of heartburn. Timepoint: Before intervention, 2 and 4 weeks after commencement, at the end of intervention. Method of measurement: Myoclinic questionnaire.;Frequency of epigastric pain. Timepoint: Before intervention, 2 and 4 weeks after commencement, at the end of intervention. Method of measurement: Myoclinic questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAfsane Shakeri
Tehran University of Medical Sciences
Outcome results
None listed