Contrast induced nephropathy. Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
Conditions
Interventions
For the case group from 48 hours before performing angiography Atorvastatin 80 mg/day and for the control group placebo was prescribed. Then all of case and control groups recieved isotonic saline a
Treatment - Drugs
Sponsors
Baqiyatallah university of medical science
Eligibility
Sex/Gender
All
Age
55 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: diabetes mellitus (FBS> 126, Random BS> 200, GTT> 200); chronic renal failure (creatinine higher than 1.5 mg/dl or GFR less than 60) Exclusion criteria: recent treatment with statin 80 mg; patients requiring emergency angiography; contraindications to prescribe statins; Patients with previous contrast media administration during the last 10 days; Patients with chronic dialysis treatment; patients with informed refusal of consent
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BUN. Timepoint: before-24 hr and 48 hr after intervention. Method of measurement: blood sampling.;Creatinine. Timepoint: before-24 hr and 48 hr after intervention. Method of measurement: blood sampling.;HB. Timepoint: befor intervention. Method of measurement: blood sampling.;LVEF. Timepoint: befor intervention. Method of measurement: echocardiography.;Lipid profile. Timepoint: befor intervention. Method of measurement: blood sampling.;CIN. Timepoint: 24 hr and 48 hr after intervention. Method of measurement: an increasing serum creatinine more than 0.5mg/dl or more than 25% from the base. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHesam sadat Hashemi
Baqiyatallah university of medical science
Outcome results
None listed