gastroesophageal reflux. Gastro-esophageal reflux disease
Conditions
Interventions
Intervention 1: Intervention group: Tablet Lansoprazole 30 mg daily with Capsule Duloxetine 30 mg daily(Abidi company). Intervention 2: Control group: Tablet Lansoprazole 30 mg daily with Capsule plac
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: age between 18-65 Typical symptoms of Gastro -esophageal reflux disease (heartburn, regurgitation)and/ or endoscopic findings of Gastroesophageal reflux disease
Exclusion criteria
Exclusion criteria: Use of recent or previous anti-depressants and anti- anxiety drugs A history of allergy to any of the medications History of alcohol consumption Atypical symptoms of Gastro esophageal reflux disease Previous history of anxiety or depression History of opium use History of upper gastrointestinal disorders(Dyspepsia and/or Peptic ulcer disease) History of cardiac , pulmonary , musculoskeletal disease and any malignancy. History of medications such as: Sildenafil, calcium channel blocker, methylxanthine, nitrate and beta-agonist Age under 18 years Age older than sixty-five
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality and symptoms of patients with gastroesophageal reflux Disease. Timepoint: Before starting the intervention and 4 weeks later. Method of measurement: Patient Assessment of gastroesophageal re flux Quality of life and symptom Questionnaires. | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse effect of medications. Timepoint: 2 and 4 weeks after starting the intervention. Method of measurement: Data gathering sheet of patients. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMarjan Mokhtare
Iran University of Medical Sciences
Outcome results
None listed