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Effect of sodium mannuronate ointment in osteoarthritis treatment

Comparison of clinical effects of sodium mannuronate and salicylate ointments in the reduction of activity and symptoms of disease in patients with osteoarthritis

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2014113013739N3
Enrollment
50
Registered
2015-02-15
Start date
2014-12-22
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis. Polyartherosis

Interventions

Intervention 1: Control group will be treated topically 3 times per day for 30 days with Salicylate ointment produced by Sobhan Darou Co. Intervention 2: Treatment group will be treated topically 3 ti
Treatment - Drugs
Control group will be treated topically 3 times per day for 30 days with Salicylate ointment produced by Sobhan Darou Co.
Treatment group will be treated topically 3 times per day for 30 days with non-steroidal ointment called Mannuronate sodium which its effective material has been produced in department of immunology,

Sponsors

Vice chancellor for research, Tehran University of Medical Sciences (Major supporter)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients with osteoarthritis in the age range of 35 to 75 years, according to the diagnostic criteria of American College of Rheumatology which at the first visit by a specialist in rheumatology and then by laboratory and radiological parameters are diagnosed. Exclusion criteria: history of fever and infectious diseases, pregnancy and breast feeding, other autoimmune diseases, cancers and malignancies, the involvement of patients in the other clinical trials during the past 4 weeks, other diseases simultaneously (hepatic, nephrotic, hematologic, gastrointestinal, endocrine, cardiovascular, respiratory, neurologic or cephalic)

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Osteoarthritis activity. Timepoint: Before intervention and one month after intervention. Method of measurement: Questionnaire.

Secondary

MeasureTime frame
Pain. Timepoint: Before intervention and one month after intervention. Method of measurement: Questionnaire.;Stiffness. Timepoint: Before intervention and one month after intervention. Method of measurement: Questionnaire.;Physical performance. Timepoint: Before intervention and one month after intervention. Method of measurement: Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAbbas Mirshafiey

Tehran University of Medical Sciences

mirshafiey@tums.ac.ir+98 21 8895 4913

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026