Upper gastrointestinal haemorrhage. Haematemesis
Conditions
Interventions
Intervention 1: Intervention group: after standard treatment of upper GI bleeding, these patients would receive intravenously 1 gr tranexamic acid (100 and 250 mg vials are available) in 10 minutes, t
Treatment - Drugs
Behavior
Intervention group: after standard treatment of upper GI bleeding, these patients would receive intravenously 1 gr tranexamic acid (100 and 250 mg vials are available) in 10 minutes, then 1 gr tranexa
Control group: after standard treatment of upper GI bleeding, these patients would receive normal saline as placebo, as same the intervention group, first in a vial in 10 minutes and then slow intrave
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: All patients with signs and symptoms of upper gastrointestinal bleeding, which will present to emergency ward and have all of these conditions: age more than 18 years old and hemodynamically stable condition(systolic blood pressure more than 90 mmHg and pulse rate less than 110 bpm), as well as accept to contribute in the study(by consent form). Exclusion criteria: age less than 18 years old; pregnancy and breast feeding; Tranexamic Acid contraindications: history of thromboembolic disorders, nephrotic syndrome, current estrogen consumption, history of allergy to tranexamic acid or variceal hemorrhage; patients that need to anticoagulant therapy; probable DIC; history of epilepsy or brain disorders; cancer ( except for who has been treated and no recurrence has occurred in one years ago).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decrease in mortality of upper gastrointestinal bleeding. Timepoint: one week. Method of measurement: Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Decrease in rebleeding. Timepoint: 24 houres. Method of measurement: Questionnaire.;Decrease in need to endoscopic treatment. Timepoint: 24 houres. Method of measurement: Questionnaire.;Decrease in need to blood component transfusion. Timepoint: first week. Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSanaz Javdani Masroor Tanha
Mashhad University of Medical Sciences
Outcome results
None listed