Efficacy of premedication with dextromethorphan and gabapentin alone or in combination for postoperative pain management in ligament of knee surgery

Efficacy of premedication with dextromethorphan and gabapentin alone or in combination for postoperative pain management in ACL and PCL knee arthroscopy with general anesthesia

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141127020112N9

Enrollment

114

Registered

2019-06-16

Start date

2017-09-01

Completion date

Unknown

Last updated

2019-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Efficacy of premedication with dextromethorphan and gabapentin alone or in combination for postoperative pain management in ACL and PCL knee arthroscopy with general anesthesia. Sprain of cruciate ligament of knee

Interventions

Intervention 1: Intervention group 1 : 100 mg oral Gabapentine, 1hour before surgery. Intervention 2: Intervention group 2: 1mg/kg oral Dextromethorphan 1hour before surgery. Intervention 3: Intervent

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: All patient for knee arthroscopy surgery under general anesthesia 18 to 60 years old ASA 1-2 class

Exclusion criteria

Exclusion criteria: history of sensitivity to drugs that used in study Opium addiction

Design outcomes

Primary

Measure	Time frame
Pain rate. Timepoint: NRS scale at 0, 2, 4, 8, 12, and 24 hours. Method of measurement: Numeric Rating Scale ; Ramsay.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactPooya Derakhshan

Iran University of Medical Sciences

Pooya_derakhshan@bums.ac.ir+98 21 8163 3685

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026