Pain. Unspecified pain
Conditions
Interventions
Intervention 1: 200 mg oral celecoxib single dose 1 hour before surgery. Intervention 2: 400 mg oral ibuprofen single dose 1 hour before surgery. Intervention 3: one tablet of vitamin B single dose 1
Treatment - Drugs
Placebo
200 mg oral celecoxib single dose 1 hour before surgery
400 mg oral ibuprofen single dose 1 hour before surgery
one tablet of vitamin B single dose 1 hour before surgery
Sponsors
Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: (a) age of 18 to 60 years; (b) candidate for laparotomy; (c) drug dependence. Exclusion criteria: (a) using analgesic during 8 hours before surgery; (b) during pregnancy of breastfeeding; (c) sensitivity to celecoxib, ibuprofen, or vitamin B; (d) affected with cardiovascular diseases, renal diseases, liver diseases, and gastrointestinal diseases; (e) alcohol abuse.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measuring the pain severity. Timepoint: 1 and 6 hours after surgery. Method of measurement: using VAS scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of narcotic or analgesic used. Timepoint: during the 6 hours after surgery. Method of measurement: by checking medical record. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactElham Khorshidi
Elham Khorshidi
Outcome results
None listed