aphtous ulcers. Recurrent oral aphthae
Conditions
Interventions
Intervention 1: putting 1 cm in length of Propolis gel on aphtous ulcers 4 time a day for 6 days. Intervention 2: putting 1 cm in length of orabase gel (placebo) on aphtous ulcers 4 time a day for 6 d
Treatment - Drugs
Placebo
putting 1 cm in length of Propolis gel on aphtous ulcers 4 time a day for 6 days
putting 1 cm in length of orabase gel (placebo) on aphtous ulcers 4 time a day for 6 days
Sponsors
Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: (a) age of 15 to 60 years; (b) having recurrent minor aphtous ulcers; (c) history of disease for more than one year with at least two recurrence a year; (d) having 1 to 6 ulceration if each episode; (e) less than 72 hours from the begging of the ulceration; (f) the duration of healing without medication is not more than 7 days; (g) the size of ulcers is not more than 1 cm. Exclusion criteria: (a) hypersensitivity to drug or plant; (b) treatment with immunosuppressive drugs during the last month; (c) using systemic antibiotic during the last two weeks; (d) using anti-inflammatory drugs or anti-histamine during the last month; (e) using any drug for treatment of aphtous ulcers during the last 72 hours; (f) having systemic diseases such as endocrine, immunologic, hematologic, metabolic, rheumatoid arteritis, and hormonal disorders; (g) during pregnancy or breastfeeding; complete or partial denture or unsuitable restoration of a tooth or appliance ortodency in close contact with aphtous ulcers; (h) cigarette smoking or drinking alcohol; (i) affected with major aphtous ulcers or herpetiform ulcers.
Exclusion criteria
Exclusion criteria:
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Presence of erythema or exudates. Timepoint: 3 and 6 days after treatment. Method of measurement: by physical examination. | — |
Primary
| Measure | Time frame |
|---|---|
| Measuring the diameter of lesions. Timepoint: before and 3 and 6 days after treatment. Method of measurement: by physical examination.;Measuring the pain severity. Timepoint: before and 3 and 6 days after treatment. Method of measurement: by taking history. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAzadeh Moslemkhani
Dentistry School
Outcome results
None listed