pneumonia. Pneumonia, unspecified
Conditions
Interventions
Intervention 1: First group(intervention): 90 patients
from the beginning until the end of hospitalization intravenous Ranitidine 50 mg will be given three times a day and after tolerating oral nutrition will be continued 150 mg twice a day. Intervention
starting treatment with intravenous pantoprazole 40Mg twice a day from the beginning of hospitalization and will be continued until the releasing time. After tolerating oral nutrition pantoprazole 40m
Treatment - Drugs
First group(intervention): 90 patients
from the beginning until the end of hospitalization intravenous Ranitidine 50 mg will be given three times a day and after tolerating oral nutrition will be continued 150 mg twice a day.
Second group (control):90 patients
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteriona: hospitalized intubated patients in intensive care unit of Imam Reza hospital during the study. Exclusion criteria: patients showing allergic reactions to ranitidin and pantoprazol; patients with active lung disease before receiving these two drugs; patients with active gastrointestinal bleeding at the beginning of our study; immune compromised patients or the history of receiving antibiotics or any factor that changes the immune condition toward VAP.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decreased incidance of ventilator associated pneumonia in intubated patients under mechanical ventilation. Timepoint: End of stay in the ICU. Method of measurement: Diagnostic criteria for VAP are: new infiltration in CXR plus two criteria of these three criteria:1.fever higher than 38.5,2.leukocytes more than 100000,3.pus in suctioning the tracheal tube secretion.the final diagnosis for VAP is based on the culture of the tracheal tube secretion.the existence of more than 100000 bacterial colony count will be positive. | — |
Secondary
| Measure | Time frame |
|---|---|
| Fever more than 38.5 degree. Timepoint: Every day. Method of measurement: Thermometer.;Lekusytosis more than 10000. Timepoint: Every day. Method of measurement: CBC.;Colony count more than 100000 in tracheal tube culture. Timepoint: Every day. Method of measurement: Tracheal tube specimen culture.;New infiltration in CXR. Timepoint: Every week. Method of measurement: Chest X Ray. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Sara Rozmina
Mashhad University of Medical Sciences
Outcome results
None listed