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Effects of melatonin alone and with vitamin C in the treatment of periodontitis

The effects of antioxidant supplements melatonin alone and in combination with vitamin C on the clinical characteristics of periodontal treatment phase

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2014112410155N2
Enrollment
69
Registered
2015-02-15
Start date
2014-12-09
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Relationship between antioxidant supplements with melatonin alone and Bavytamyn C on clinical periodontal index of treatment phase.

Interventions

Intervention 1: Control chart completion, scaling and brushing by handheld devices, ultrasonic and Rabrkp and paste pumice, administered placebo for 30 days. Intervention 2: Group 2 (intervention), ch
Placebo
Treatment - Drugs
Control chart completion, scaling and brushing by handheld devices, ultrasonic and Rabrkp and paste pumice, administered placebo for 30 days.
Group 2 (intervention), chart completion, scaling and brushing by handheld devices, ultrasonic and Rabrkp and paste pumice, administration of melatonin tablets 2 mg, once a day, for 30 days
Group 3 (intervention), chart completion, scaling and brushing by handheld devices, ultrasonic and Rabrkp and pumice paste, oral administration of melatonin 2 mg, once a day, for 30 days and 60 mg vit

Sponsors

Tabriz University of Medical Sciences, School of Dentistry, Tabriz, gum disease and tooth Research C
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients older than 20 years old with will be enrolled with the following criteria : 1.Patients with Moderate periodotitis; 2.Patients must have teeth excluding third molars in function 3. The absence of systemic disease 4. Full mouth score plaque above 25%; 5 .Non- use of antibiotics in the last three months 6.Willingness to participate in the study.Exclusions criteria of the study are as follow: 1. Pregnancy and lactation; 2. Systemic disease; 3.Of any kind of drugs , tabaco, alcohol; 4.Failure to establish any of the terms of inclusion

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Clinical attachment level (CAL). Timepoint: Befoer the experiment (Baseline) , 3 months after the intervention, 6 month after the intervention. Method of measurement: Measured the distance between the bottom of the stent sulcus by periodontal probe.

Secondary

MeasureTime frame
Plaque. Timepoint: Before the experiment , (Baseline) , 3 months after the intervention, 6 months afte ther intervention. Method of measurement: Disclosing agent by visual scale.;Bleeding on probing (BOP). Timepoint: Before the experiment (Baseline) , 3 months afterthe intervention, 6 months afterintervention. Method of measurement: Bleedingfor 15 seconds afte rgentle probing by periodontal probe.;Probing depth (PD). Timepoint: Before the experiment, three months after the intervention, six months after the intervention. Method of measurement: The distance between the bottom of the sulcus by marginal mucosa and periodontal probe in mm.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mohammad Taghi Chitsazi

Gum disease and tooth Research Center, School of Dentistry, Tabriz

mtchitsazi@gmail.com00

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026