Effect of acyclovir-melissa nanofiber patch in treatment of recurrent herpes labialis

Comparison of remission index of nanofiber loading acyclovir- melisa and nanofiber loading acyclovir and mucoadhesive cream formula on Recurrent-Herpes-Labialis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141124020073N3

Enrollment

Registered

2022-02-20

Start date

2021-09-11

Completion date

Unknown

Last updated

2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Recurrent Herpes Labialis. Herpesviral vesicular dermatitis

Interventions

Intervention 1: Intervention group: acyclovir-melissa nanofiber patch: Active ingredients are acyclovir in the class of antiviral drugs, and Melissa Officinalis a herb containing polyphenolic compound

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Maximum interval of 48 hours since the emergence of the lesion Having a recurrent lesion (i.e., secondary) Receiving no antiviral, anti-inflammatory, steroid, or analgesic drugs Vesicular stage of the lesion and lesion size <1 cm

Exclusion criteria

Exclusion criteria: Allergies to the used herbal medicines Hepatic, renal, or systemic diseases Use of birth control pills Breastfeeding

Design outcomes

Primary

Measure	Time frame
Symptoms of patient discomfort (pain, itching, burning sensation). Timepoint: Daily measurement of the symptoms from the beginning of treatment (baseline) until the symptoms disappeared. Method of measurement: Using a numerical scale, ranging from 0 to 10.;Crusting time. Timepoint: As soon as evidence of crusting was observed in the daily images taken and sent by patients, the patient was referred for clinical examinations. Method of measurement: Clinical examination.;Healing time. Timepoint: As soon as evidence of healing was observed in the images, the patient was referred for clinical examinations. Method of measurement: Clinical examination.	—

Measure

Time frame

Symptoms of patient discomfort (pain, itching, burning sensation). Timepoint: Daily measurement of the symptoms from the beginning of treatment (baseline) until the symptoms disappeared. Method of measurement: Using a numerical scale, ranging from 0 to 10.;Crusting time. Timepoint: As soon as evidence of crusting was observed in the daily images taken and sent by patients, the patient was referred for clinical examinations. Method of measurement: Clinical examination.;Healing time. Timepoint: As soon as evidence of healing was observed in the images, the patient was referred for clinical examinations. Method of measurement: Clinical examination.

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Countries

Iran (Islamic Republic of)

Contacts

Public Contactzahra Golestannejad

Esfahan University of Medical Sciences

golestannejad@dnt.mui.ac.ir+98 31 3792 5515

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026