Acute myocardial infarction. myocardial infarction specified as acute or with a stated duration of 4 weeks (28 days) or less from onset
Conditions
Interventions
Intervention 1: Minocycline 50 mg orally at baseline and then 50 mg daily for 5 days. Intervention 2: Placebo in the form of the main drug orally at baseline and then daily for 5 days.
Treatment - Drugs
Placebo
Minocycline 50 mg orally at baseline and then 50 mg daily for 5 days
Placebo in the form of the main drug orally at baseline and then daily for 5 days
Sponsors
Tehran Heart Center
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: inclusion criteria: 1- Diagnosis of STEMI (chest pain>30 minutes and 1 mm in at least 2 consecutive leads) 2- No history of heart failure 3- Giving consent to enter the study 4- Age>20 and <65 years 5- Successful PCI exclusion criteria: 1- History of myocardial infarction 2- History of cardiac surgery (either CABG or valvular surgery) 3- History of electrophysiological interventions (ablation or device implantation) 4- Presence of cardiogenic shock at the time of admission 5- Chronic diseases with poor survival (malignancy, etc.) 6- Cardiomyopathy or hereditary muscular diseases 7- Chronic renal or hepatic insufficiency 8- new onset left bundle branch block in ECG 9- candidate for antithrombolytic therapy 10- Moderate to severe mitral regurgitation
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left ventricular function. Timepoint: Baseline (within 48 hours from PCI) and 6 months later. Method of measurement: Echocardiography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Diastolic function. Timepoint: Baseline (within 48 hours from PCI) and 6 months later. Method of measurement: Echocardiography.;Tissue doppler indices. Timepoint: Baseline (within 48 hours from PCI) and 6 months later. Method of measurement: Color Doppler Echocardiography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAlireza Nasiri
Tehran Heart Center
Outcome results
None listed