Anal fissure. Anal fissure
Conditions
Interventions
Intervention 1: Intervention group: The first group will receive topical jel diltiazem 2% produced by Sobhan daroo co. two times per day q 12 hours. Intervention 2: Control group: The second group wil
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Symptoms of anal fissure (pain, bleeding, burning, or itching) in the last six weeks. Finding one of the following signs on examination: visible sphincter fibers at the fissure base, anal papillae, sentinel piles, and indurated margins.
Exclusion criteria
Exclusion criteria: Past history of anal surgery Current consumption of other topical or oral medication for anal fissure. History of allergic reaction to diltiazem. History of cardiovascular problems including sick sinus syndrome, heart block, arrhythmia, bradycardia, heart failure, and cardiomyopathy. Hypotension (systolic blood pressure < 90 mmHg). History of chronic liver failure. Current consumption of antihypertensive drugs. Pregnancy and breast feeding. Failure to obtain informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity. Timepoint: Before treatment and four weeks treatment. Method of measurement: Visual analog scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Itching. Timepoint: Before treatment and four weeks treatment. Method of measurement: Inquiring the patient about presence or absence of itching.;Bleeding. Timepoint: Before treatment and four weeks treatment. Method of measurement: Inquiring the patient about presence or absence of bleeding.;Side effects including hives, hypotension, vertigo, palpitation, light headedness. Timepoint: Four weeks post-treatment. Method of measurement: Inquiring the patient about presence or absence of side effects. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactEhsan Karimialavijeh
Tehran University of Medical Sciences
Outcome results
None listed