Propofol plus paracetamol in benign headaches.

Evaluating the effectiveness of intravenous Propofol plus paracetamol versus paracetamol alone in benign headaches, a randomized placebo controlled clinical trial.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141116019971N4

Enrollment

Registered

2019-09-02

Start date

2019-08-19

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Headache. Headache

Interventions

Intervention 1: Intervention group: receives 1gr of intravenous paracetamol in 100 ccs normal saline over 20 minutes and 1mg/kg intravenous propofol. Medications:

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age 18 years and above Benign headaches

Exclusion criteria

Exclusion criteria: Suspicious to secondary headaches based on the attending physician's judgment Abnormal vital signs Variation in the level of consciousness Fever Focal neurologic defficite Pregnancy Allergy to the egg yolk, acetaminophen or propofol Neck stiffness Hepatic failure an chronic liver disease

Design outcomes

Primary

Measure	Time frame
Pain intensity. Timepoint: 0,10, 20, 30, 60 minutes. Method of measurement: Numeric rating scale.	—

Secondary

Measure	Time frame
Blood pressure. Timepoint: 0,10, 20, 30, 60 minutes. Method of measurement: Blood pressure cuff.;Heart rate. Timepoint: 0,10, 20, 30, 60 minutes. Method of measurement: Cardiac monitoring device.;Oxygen saturation. Timepoint: 0,10, 20, 30, 60 minutes. Method of measurement: Puls oxymeter.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMojtaba Aghili

Tehran University of Medical Sciences

aghili220@yahoo.com+98 21 6690 4848

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026