Chronic Obstructive Pulmonary Disease. Chronic obstructive pulmonary disease with acute exacerbation, unspecified
Conditions
Interventions
Intervention 1: intervention in control group: receive 5 cc of sterile water in 50 cc normal saline. Intervention 2: intervention in case group: infusion of 2.5 grams of Mgso4 in 50 cc normal saline i
Sponsors
Vice Chanceller for research of Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: patient older than 18 years acute exacerbation of COPD
Exclusion criteria
Exclusion criteria: any other underlying causes for dyspnea including heart failure, asthma, renal failure, pneumothorax, pneumoni Not willingness to participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subjective improvement of dyspnea. Timepoint: First time after the initial dose of nebulized bronchodilator and second time after the treatment protocol (3 doses of bronchodilators and even Magnesium or placebo infusion). Method of measurement: patient were asked about severity of dyspnea based on the 10 point likert scale.;Peak Expiratory Flow Rate(PEFR) improvement. Timepoint: First time after the initial dose of nebulized bronchodilator and second time after the treatment protocol (3 doses of bronchodilators and even Magnesium or placebo infusion). Method of measurement: Peak-flow-metry. | — |
Secondary
| Measure | Time frame |
|---|---|
| Intubation during the course of admition. Timepoint: any time during first 12 hours of admition. Method of measurement: Based on patients records.;Length of hospital stay. Timepoint: time of discharge from hospital. Method of measurement: Based on patients records. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactElnaz Vafadar Moradi
Mashhad University of Medical Sciences - Imam Reza hospital
Outcome results
None listed