Acute exacerbation of asthma. Unspecified asthma with (acute) exacerbation
Conditions
Interventions
Intervention 1: Intervention group: 250 mg aminophylline ( from 25 mg/ml solution) is nebulized for the patient via a face mask by a compressor nebulizer within 15 minutes. Intervention 2: Control gro
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patient older than 18 years old presented by severe asthma attack
Exclusion criteria
Exclusion criteria: Not consent for participating in the study Uncooperative for nebulizer use Contra-indications for aminophylline Pregnancy History of tachy-dysrhythmia Drug history of resent theophylline use
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Admission rate. Timepoint: After 12 hours of treatment initiation. Method of measurement: Admission to inpatient wards or discharge from emergency department.;Changes in peak expiratory flow rate. Timepoint: After one hour of treatment. Method of measurement: peak-flow meter. | — |
Secondary
| Measure | Time frame |
|---|---|
| Need to intubation. Timepoint: One hour after intervention. Method of measurement: Intubated or not intubated (observation).;Severity of dyspnea. Timepoint: One hour after intervention. Method of measurement: Visual Analogue Scale.;Occurrence of adverse events of aminophylline (tachycardia, seizure, dysrhythmia and hypertension). Timepoint: One hour after intervention. Method of measurement: observation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactElham Pishbin
Mashhad University of Medical Sciences
Outcome results
None listed