Licorice gargling to decrease sore throat after surgery

An evaluation of the efficacy of different doses of licorice gargling for attenuating postoperative sore throat after tracheal intubation

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201411115362N21

Enrollment

144

Registered

2015-01-19

Start date

2013-01-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Postoperative Sore Throat (POST). Condition 2: Postextubation Cough. Pain in throat Cough

Interventions

Intervention 1: Group A: Licorice (Gargling, 0.25 gram Licorice in 30 ml of water, 5min before operation, for 30 seconds). Intervention 2: Group B: Licorice (Gargling, 0.5 gram Licorice in 30 ml of wa

Prevention

Treatment - Drugs

Group A: Licorice (Gargling, 0.25 gram Licorice in 30 ml of water, 5min before operation, for 30 seconds)

Group B: Licorice (Gargling, 0.5 gram Licorice in 30 ml of water, 5min before operation, for 30 seconds)

Group C: Licorice (Gargling, 1 gram Licorice in 30 ml of water, 5min before operation, for 30 seconds)

Group D (Control group): Placebo (Gargling, only 30 ml of water, 5min before operation, for 30 seconds)

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:Patients underwent any operation other than head and neck surgery under general anesthesia; aged between 18 and 65 years; with American Society of Anesthesia (ASA) physical status I and II; no NSAID use; no perioperative corticosteroid intake (from 24 hours before operation); no allergy or intolerance to licorice; no upper respiratory tract infection; without mallampati grade more than two. Exclusion criteria: Any change in anesthetic technique; requiring more than one attempt for intubation; not being extubated at the end of the surgery; re-intubation within the study period.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Postoperative Sore Throat. Timepoint: 0, 2, 4, and 24 hours after operation. Method of measurement: Visual Analogue Scale.	—

Secondary

Measure	Time frame
Postextubation Cough. Timepoint: after extubation. Method of measurement: Observation.;Patient Satisfation. Timepoint: 24 hours after operation. Method of measurement: Likert form asked from patient (very satisfied, satisfied, no opinion, dissatisfied, very dissatisfied).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Mohammadreza Safavi

Isfahan University of Medical Sciences

safavi@med.mui.ac.ir+98 913 315 2416

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026