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The Analgesic Effects Of Ketamine- Methylprednisolone versus Methyl Prednisolone in Knee Osteoarthritis Patients

Comparison of analgesic effects of intraarticular ketamine- Methylprednisolone and Methylprednisolone in knee osteoarthritis patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2014111119902N1
Enrollment
70
Registered
2015-01-10
Start date
2014-08-23
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain. Analgesics, antipyretics and anti-inflammatory drugs

Interventions

Intervention 1: Group I: Intra-articular injection of 40 mg/ml methylprednisolone and 1 ml sterile water in the operation room. Intervention 2: Group II: Intra-articular injection of 40 mg/ml methylpr
Placebo
Prevention
Group I: Intra-articular injection of 40 mg/ml methylprednisolone and 1 ml sterile water in the operation room.
Group II: Intra-articular injection of 40 mg/ml methylprednisolone and 0.5 mg/kg ketamine in the operating room.

Sponsors

Vice chancellor for research, Ahwaz Jondishapour University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Pain due to arthritis; at least one month of unsuccessful treatment; positive radiological findings. Exclusion criteria: Pain due to inflammatory diseases; history of fractures of the knee; ankylosis of the knee; previous deformity such as genu varum; immunodeficiency; infection at the injection site; drug addiction; meniscal and ligament injuries of the knee; coagulation disorders.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: One and Three Months After Injection. Method of measurement: visual analog scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactReza Akhondzadeh

Imam Khomeini Hospital

akhondzade-r@ajums.ac.ir+98 61 3221 6504

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026