Comparison of oral versus vaginal misoprostol for legal abortion

Comparison of oral versus vaginal misoprostol for legal abortion in pregnant women: A double blind randomized clinical study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014110812789N9

Enrollment

Registered

2014-12-13

Start date

2014-04-04

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Medical abortion. termination of pregnancy

Interventions

Intervention 1: Intervention group: misoprostol 200 mcg tablets (Cytotec) were used vaginally every 6 hours up to 6 times up to 36 hours. Tablets were inserted into the depth of vagina by the midwife.

Treatment - Drugs

Intervention group: misoprostol 200 mcg tablets (Cytotec) were used vaginally every 6 hours up to 6 times up to 36 hours. Tablets were inserted into the depth of vagina by the midwife. Generic name: M

Control group: misoprostol 200 mcg tablets (Cytotec) were used orally every 6 hours up to 6 times up to 36 hours. Generic name: Misoprostol Brand name: Cytotec

Eligibility

Sex/Gender

Female

Age

15 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: pregnant women who are candidates of pregnancy termination with the permission of legal Medicine. Exclusion criteria : pregnant women who are breastfeeding, women with severe liver disease, chronic pulmonary disease, Mitral valve stenosis, history of allergy to prostaglandins, inflammatory disease of intestines, asthma, glaucoma, hypertension, and severe bleeding.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pregnancy Exertion. Timepoint: Beginning of the study, every 6 hours up to 36 hours. Method of measurement: dilatation of cervix-contraction and hemorrhage.	—

Secondary

Measure	Time frame
Fever. Timepoint: Every one hour until the last dosage. Method of measurement: Clinical Examination.;Uterus perforation. Timepoint: Every one hour until the last dosage. Method of measurement: Clinical examination by Gynecology resident.;Amount of bleeding. Timepoint: The start of the intervention up to 36 hours. Method of measurement: Observation and clinical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFaeze Malak Mohammadi Memar

Kurdistan University of Medical Sciences

faezeh_malekmohammadi@yahoo.com+98 87 3328 8119

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026