Type II diabetes mellitus. Non-insulin-dependent diabetes mellitus
Conditions
Interventions
Intervention 1: supplementation tablet probiotic in intervention group: Each probiotic tablet is comprised of 100 mg Lactol probiotic. Lactol probiotic include Lactobacillus coagulans and Fructooligos
Treatment - Drugs
Placebo
supplementation tablet probiotic in intervention group: Each probiotic tablet is comprised of 100 mg Lactol probiotic. Lactol probiotic include Lactobacillus coagulans and Fructooligosaccharides (FOS)
placebo in control group: Each placebo tablet contained farina. Placebo tablets were produced by Pharmaceutics department of Mashhad School of Pharmacy.
Sponsors
Sabzevar University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients affected to diabetes melitus type 2; body mass index <35 kg/m2; patients enrolled in this study should have no infectious disease, hepatitis or renal diseases. Exclusion criteria: patients received cholesterol-lowering drugs, probiotic, prebiotic and omega-3 fatty acids and antibiotics from 1 month before and during the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammation factors (CRP, IL-6 and TNF). Timepoint: Baseline (before initiating intervention) and 8 weeks after initiating intervention. Method of measurement: Enzyme-like immune- sorbent assay (ELISA) kits (Monobind, Inc., Lake Forest, Calif., USA). | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum lipid profile (LDL, HDL, total). Timepoint: Baseline and the end of week 8. Method of measurement: Kits of Pars Test company and Auto analyzer Selectra 2 methods. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBibi Leila Hoseini
Sabzevar University of Medical Sciences
Outcome results
None listed