Selenium supplementation effects on polycystic ovarian syndrome

Selenium supplementation effects on serum asymmetric dimethylarginine (ADMA) ,free androgen index (FAI) and visceral adiposity index (VAI) in women with polycystic ovary syndrome ; randomized clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014110519813N1

Enrollment

Registered

2014-12-08

Start date

2014-11-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

polycystic ovarian syndrome. Polycystic ovarian syndrome

Interventions

Intervention 1: selenium, 200 microgram capsul, once a day for 3 month. Intervention 2: placebo, once a day for 3 month.

Treatment - Drugs

Placebo

selenium, 200 microgram capsul, once a day for 3 month

placebo, once a day for 3 month

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: The inclusion criteria are as follows: women between 18 and 45 years old; diagnosed PCOS based on the Rotterdam criteria; non smokers the exclution criteria are : having an androgen-secreting tumor, Cushing syndrome, congenital adrenal hyperplasia, hyperprolactinemia, and/or virilism; impaired fasting glucose; diabetes, hypothyroidism; hyperthyroidism; liver disease; renal dysfunction; cardiovascular disease or dysfunction; pregnancy or breas feeding; taking medications known to affect metabolic parameters , such as corticosteroid drugs , ocp, selenium or multivitamin and mineral supplements -

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
ADMA. Timepoint: before - after 3 month treatment. Method of measurement: by elisa kit.;Serum cholesterol. Timepoint: before - after 3 month treatment. Method of measurement: kit.;Fasting blood sugar. Timepoint: before - after 3 month treatment. Method of measurement: torbidmetry.;Serum triglyseride. Timepoint: before - after 3 month treatment. Method of measurement: kit.;HDL. Timepoint: before - after 3 month treatment. Method of measurement: kit.;LDL. Timepoint: before - after 3 month treatment. Method of measurement: friedewald equation.;APO AI. Timepoint: before - after 3 month treatment. Method of measurement: kit.;APO B100. Timepoint: before - after 3 month treatment. Method of measurement: kit.;Fasting serum insulin level. Timepoint: before - after 3 month treatment. Method of measurement: kit.;Testosterone. Timepoint: before - after 3 month treatment. Method of measurement: kit.;SHBG. Timepoint: before - after 3 month treatment. Method of measurement: kit.;Weihgt. Timepoint: before - after 3 month treatment. Method of measurement: scale.;Waist cicumfrence. Timepoint: before - after 3 month treatment. Method of measurement: Centimeter.;Hip circumfernce. Timepoint: before - after 3 month treatment. Method of measurement: Centimeter.	—

Measure

Time frame

ADMA. Timepoint: before - after 3 month treatment. Method of measurement: by elisa kit.;Serum cholesterol. Timepoint: before - after 3 month treatment. Method of measurement: kit.;Fasting blood sugar. Timepoint: before - after 3 month treatment. Method of measurement: torbidmetry.;Serum triglyseride. Timepoint: before - after 3 month treatment. Method of measurement: kit.;HDL. Timepoint: before - after 3 month treatment. Method of measurement: kit.;LDL. Timepoint: before - after 3 month treatment. Method of measurement: friedewald equation.;APO AI. Timepoint: before - after 3 month treatment. Method of measurement: kit.;APO B100. Timepoint: before - after 3 month treatment. Method of measurement: kit.;Fasting serum insulin level. Timepoint: before - after 3 month treatment. Method of measurement: kit.;Testosterone. Timepoint: before - after 3 month treatment. Method of measurement: kit.;SHBG. Timepoint: before - after 3 month treatment. Method of measurement: kit.;Weihgt. Timepoint: before - after 3 month treatment. Method of measurement: scale.;Waist cicumfrence. Timepoint: before - after 3 month treatment. Method of measurement: Centimeter.;Hip circumfernce. Timepoint: before - after 3 month treatment. Method of measurement: Centimeter.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Mohammad Hosseinzadeh

Tehran University Of Medical Sciences

fmhosseinzade@gmail.com+98 21 8895 1395

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026