Study of Effects of Repetitive Transcranial Magnetic Stimulation on cognition of Refractory Obsessive Compulsive Disorder Patients

Study of Cognitive Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients of Refractory Obsessive Compulsive Disorder

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014110419808N1

Enrollment

Registered

2014-11-28

Start date

2014-11-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

refractory obsessive compulsive disorder. Mixed obsessional thoughts and acts

Interventions

Intervention 1: Intervention (refractory transcranial magnetic stimulation (rTMS)): high frequency left (HFL) stimulation will initially be applied at 20 Hz, in 25 trains of 1.5 second duration with a

Then following this, high frequency right (HFR) stimulation will be applied at the same parameters. Therefore a total of 50 minutes of stimulation will be delivered. Intervention 2: Control (Sham cond

Treatment - Devices

Intervention (refractory transcranial magnetic stimulation (rTMS)): high frequency left (HFL) stimulation will initially be applied at 20 Hz, in 25 trains of 1.5 second duration with a 30 second inter

Then following this, high frequency right (HFR) stimulation will be applied at the same parameters. Therefore a total of 50 minutes of stimulation will be delivered.

Control (Sham condition): Sham stimulation will be made at the site of active treatment but with only "the side edge" resting on the scalp. It will be administered as high frequency left (HFL) and hig

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: have a DSM-IV-TR diagnosis of OCD; ages between 18 and 65 years old; have failed to achieve a clinical response, or did not tolerate, at least 3 separate antidepressant trials of sufficient dose (included clomipramine) and CBT for at least 10 weeks; score of greater than or equal to 17 on the Y-BOCS. Exclusion Criteria: a history of DSM-IV-TR substance dependence in the last 6 months or DSM-IV-TR substance abuse in the last month; a concomitant major unstable medical or neurologic illness or have had a history of seizures; acutely suicidal; being pregnant; metal implants; if they are currently (or in the last 4 weeks) taking more than lorazepam 2 mg daily (or equivalent), monoamine oxidase inhibitors, and/or bupropion (due to its associated increased risk for seizures); Education lower than 2nd class of guidance school

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Rate of cognition in refractory OCD. Timepoint: after 10th, 20th sessions of rTMS or sham. Method of measurement: PASSAT, Digit symbol, Digit Span.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mehran Shaygan Fard

Research center for behavioral disorders and substance abuse, Hamadan University of Medical Science

mshayganfard@yahoo.com+98 81 3827 4192

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026