Evaluating the Efficacy of Surfactants, Curosurf ,Survanta and Alveofact, in Respiratory Distress Syndrome in Infants

Comparing the Efficacy of three Natural Surfactants, Curosurf ,Survanta and Alveofact, in Treatment of Respiratory Distress Syndrome in Infants

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201411028680N5

Enrollment

165

Registered

2014-11-21

Start date

2014-10-19

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neonatal respiratory distress. Respiratory distress syndrome of newborn

Interventions

Intervention 1: 1 st dose of Survanta 100 mg/kg via endotracheal tube. Intervention 2: 1 st dose of Curosurf 200 mg/kg via endotracheal tube. Intervention 3: 1 st dose of Alveofact 100 mg/kg via endot

Treatment - Drugs

1 st dose of Survanta 100 mg/kg via endotracheal tube

1 st dose of Curosurf 200 mg/kg via endotracheal tube

1 st dose of Alveofact 100 mg/kg via endotracheal tube

Eligibility

Sex/Gender

All

Age

1 Days to 1 Days

Inclusion criteria

Inclusion criteria: Inclusion criteria:Infants born at a gestational age of 36 weeks or less Exclusion criteria: congenital anomalies, birth asphyxia (Apgar score less than 4 at 5 minutes) and gestational age over 36 weeks

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Base exhess change. Timepoint: After intervention. Method of measurement: Blood gas analysis.;Pco2 Change. Timepoint: After intervention. Method of measurement: Blood gas analysis.;Duration of oxygen dependency. Timepoint: Up to 7 daye after intervention. Method of measurement: Oxygen Saturation analysis with pulsoxymetery.;CPAP Failure. Timepoint: After intrvention. Method of measurement: Blood gas analysis.	—

Measure

Time frame

Base exhess change. Timepoint: After intervention. Method of measurement: Blood gas analysis.;Pco2 Change. Timepoint: After intervention. Method of measurement: Blood gas analysis.;Duration of oxygen dependency. Timepoint: Up to 7 daye after intervention. Method of measurement: Oxygen Saturation analysis with pulsoxymetery.;CPAP Failure. Timepoint: After intrvention. Method of measurement: Blood gas analysis.

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Secondary

Measure	Time frame
Intraventricular hemorrhage. Timepoint: Up to 7 days after intervention. Method of measurement: Brain sonography.;Patent ductus arteriosus. Timepoint: Up to 7 days after intervention. Method of measurement: Echocardiography.;Broncho pulmonary dysplasia. Timepoint: up to 28 daye old. Method of measurement: Chest X-ray.;Mortality. Timepoint: Up to 28 days after intervention. Method of measurement: clinical finding.	—

Measure

Time frame

Intraventricular hemorrhage. Timepoint: Up to 7 days after intervention. Method of measurement: Brain sonography.;Patent ductus arteriosus. Timepoint: Up to 7 days after intervention. Method of measurement: Echocardiography.;Broncho pulmonary dysplasia. Timepoint: up to 28 daye old. Method of measurement: Chest X-ray.;Mortality. Timepoint: Up to 28 days after intervention. Method of measurement: clinical finding.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMussavi,Mirhadi

Tabriz University of Medical Sciences

drmussavihadi@yahoo.com+98 413272094

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026