Fluid therapy in Thyroidectomy Surgery

Comparison of the effect of fluid therapy based on plethysmographic Variability Index (PVI) and conventional method on postoperative lactate levels in patients undergoing thyroidectomy surgery

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201410285140N14

Enrollment

Registered

2017-04-19

Start date

2017-05-05

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fluid Therapy. Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis

Interventions

Intervention 1: In group A: During surgery once PVI > 13 %, a 250 mL crystalloid is infused and repeated for every 5 minutes up to three times. Intervention 2: In group B: 4-8 mL/kg/h crystalloid fl

In group B: 4-8 mL/kg/h crystalloid fluid infusion is maintained, and quick fluid infusion is initiated if mean arterial blood pressure (MAP) < 65 mmHg.

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients aged 18 to 60 years; American Society of anesthesiologists physical status class I and II; A body mass index (BMI) less than 30 kilograms per cubic meter. Exclusion criteria: History of systemic (cardiovascular, renal, hepatic, or vascular) disorders; Inadequate peripheral intravenous access; Prolonged surgery (longer than 3 hours);intraoperative dysrhythmias;

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Amounts of lactate in fluid therapy according to PVI (plethysmographic variation Index). Timepoint: On admission as well as at the end of surgery. Method of measurement: Millimole/liter , Enzymatic.	—

Secondary

Measure	Time frame
Total amount of intraoperative fluids infused after fluid therapy according to conventional method. Timepoint: End of surgery. Method of measurement: Milliliter.;Amounts of lactate in fluid therapy according to conventional method. Timepoint: on admission as well as at the end of surgery. Method of measurement: Millimole/liter, Enzymatic.;Mean arterial pressure during fluid therapy according to conventional method. Timepoint: Before anesthesia as well as 1, 2, 3, and 5 minutes after that. Method of measurement: Using patients monitoring - millimeter of mercury.;Total amounts of Urine output after fluid therapy according to conventional method. Timepoint: End of surgery. Method of measurement: Milliliter.	—

Measure

Time frame

Total amount of intraoperative fluids infused after fluid therapy according to conventional method. Timepoint: End of surgery. Method of measurement: Milliliter.;Amounts of lactate in fluid therapy according to conventional method. Timepoint: on admission as well as at the end of surgery. Method of measurement: Millimole/liter, Enzymatic.;Mean arterial pressure during fluid therapy according to conventional method. Timepoint: Before anesthesia as well as 1, 2, 3, and 5 minutes after that. Method of measurement: Using patients monitoring - millimeter of mercury.;Total amounts of Urine output after fluid therapy according to conventional method. Timepoint: End of surgery. Method of measurement: Milliliter.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Ali Movafegh

Professor of Anesthesiology, Dr shariati Hospital

movafegh@sina.tums.ac.ir+98 21 8490 2282

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026