Paitients undergo direct laryngoscopy and tracheal intubation with general anesthesia. Other complications of surgical and medical care, not elsewhere classified
Conditions
Interventions
Intervention 1: In Clonidine group 0.2 mg Clonidine tablet is given 90 minutes before elective surgery and 4 ml normal saline is given intravenously 90 seconds before laryngoscopy and intubation as pl
Treatment - Drugs
In Clonidine group 0.2 mg Clonidine tablet is given 90 minutes before elective surgery and 4 ml normal saline is given intravenously 90 seconds before laryngoscopy and intubation as placebo.
In Lidocaine group a placebo tablest as the same shape of 0.2 mg Clonidine tablet is given 90 minutes before elective surgery and 1 mg/kg Lidocaine is given intravenously 90 seconds before laryngoscop
Sponsors
Tehran University of Medical Science
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria( patients older than 18 years old ; with ASA class I and II).Exclusion criteria ( patients taking drugs that affect hemodynamic or autonomic system ; obese patients(BMI>35) ; patients who have difficult airway(3 miller's criteria +) ; hypovolumic patient ; coronary arteries diseases ; respiratory; renal ; cerebral diseases ; pheochromocytoma ; hypo or hyperthyroidism ; electrocardiographic disturbances ; CHF ,diabetus mellitus ; ,uncontrolled hypertension ; mallampati ; history of allergy or contraindication for drugs used in this study ; pregnant women ; and also patients with more than one laryngoscopic trying for intubation ) .
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systolic blood presure. Timepoint: 5 minute before induction,just before laryngoscopy and 1-3-5-10 minutes after laryngoscopy and tracheal intubation. Method of measurement: blood presure manometer in mmHg.;Diastolic blood presure. Timepoint: 5 minute before induction,just before laryngoscopy and 1-3-5-10 minutes after laryngoscopy and tracheal intubation. Method of measurement: blood presure manometer in mmHg.;Mean arterial blood presure. Timepoint: 5 minute before induction,just before laryngoscopy and 1-3-5-10 minutes after laryngoscopy and tracheal intubation. Method of measurement: blood presure manometer in mmHg.;Heart rate. Timepoint: 5 minute before induction,just before laryngoscopy and 1-3-5-10 minutes after laryngoscopy and tracheal intubation. Method of measurement: counting heart ratenting. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Alireza Maziar
Tehran University of Medical Science
Outcome results
None listed