Effect of Galbanum oil on pain of the knee arthrosis

A clinical trial comparing the effects of Galbanum oil and Diclofenac gel in patients pain with osteoarthritis of the knee

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014102719699N1

Enrollment

Registered

2015-04-29

Start date

2014-10-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis. Primary gonarthrosis, bilateral

Interventions

Intervention 1: Intervention 1, topical Galbanum oil/3 time a day, Acetaminophen 500 mg/ if needed, Quadriceps femoris exercise/ 3 time a day for 4 weeks. Sixty grams of Galbanum ointment given to ea

Treatment - Drugs

Intervention 1, topical Galbanum oil/3 time a day, Acetaminophen 500 mg/ if needed, Quadriceps femoris exercise/ 3 time a day for 4 weeks. Sixty grams of Galbanum ointment given to each patient. Eac

Intervention 2, topical Diclofenac gel/ 3 time a day, Acetaminophen 500 mg/ if needed, Quadriceps femoris exercise/ 3 time a day for 4 weeks. Sixty grams of Diclofenac gel given to each patient

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: eighteen to eighty years old; at least one knee pain lasting one month; radiographic changes including osteophyte and joint space narrowing (grade 1,2,3); pregnancy test in fertile women. Exclusion criteria: active infectious disease; skin lesion in knee; renal failure; knee surgery in 2 last months; alcohol or opioid abuse; pregnancy or breastfeeding; allergy to oil.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Knee pain severity. Timepoint: Before intervention, one month and two months after intervention. Method of measurement: Visual analog scale.;Knee pain, stiffness and interference with daily activity. Timepoint: Before intervention, one month and two months after intervention. Method of measurement: WOMAC questionnaire.	—

Secondary

Measure	Time frame
Oral analgesic consumption. Timepoint: Before intervention, one month and two months after intervention. Method of measurement: Check list.;Skin hypersensitivity reactions. Timepoint: Before intervention, one month and two months after intervention. Method of measurement: Check list.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBijan Forough

Iran University of Medical Sciences

bijanfr@gmail.com+98 21 8214 1679

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026