Depression. Moderate depressive episode
Conditions
Interventions
Intervention 1: Second group will receive 20 mg Atorvastatin per day for 6 weeks. Intervention 2: First group will receive 20 mg Simvastatin per day for 6 weeks.
Treatment - Drugs
Second group will receive 20 mg Atorvastatin per day for 6 weeks.
First group will receive 20 mg Simvastatin per day for 6 weeks.
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1. Patients who have undergone coronary bypass surgery. 2. Patients who based on DSM-IV have major depression and based Hamilton rating scale for depression (Ham-D 17 items) their score is => 18. 3. No psychiatric symptoms 4. Not receiving psychotropic drugs 5. Not receiving antidepressants during the last month 6. Do not receiving ECT during the last two months 7. No thyroid problem 8. Age between 15 and 80 years 9. No liver dysfunction 10. No Muscular disorders 11. Not receiving other antilipid drugs 12. No hypersensitivity to statins 13. LDL => 80 14. Liver enzymes not being elevated at the time of recruitment 15. No life threatening disease 16. No neurological disorders 17. Not being pregnant 18. No breast feeding 19. Giving informed consent Exclusion criteria: 1. Existing other disorders rather than depression, including Bipolar disorders, Schizophrenia, and other psychotic disorders 2. History of drug abuse or dependency within the last three months 3. Probability of suicide or its tendency during the last year 4. Women who are going to be pregnant within the next few months 5. Women who use OCP for pregnancy prevention 6. Patients who have received antidepressants during the last month 7. Patients who have received ECT withing the last two months 8. Patients who need un-usual psychiatric treatments 9. Patients with liver dysfunction 10. Muscular disorders 11. Receiving other antilipid drugs 12. Hypersensitivity to statins 13. LDL < 80 14. Elevated liver enzymes at the time of recruitment 15. Life threatening diseases 16. Neurological diseases
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression. Timepoint: At the starting time, two weeks after intervention, four weeks after intervention, and six weeks after intervention. Method of measurement: Hamilton Depression Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Drugs side effects. Timepoint: First week after starting the study, second week after starting the study, fourth week after starting the study, and sixth week after starting the study. Method of measurement: Drug side effects checklist. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Seyed Hesameddin Abbasi
Tehran Heart Center
Outcome results
None listed