Hepatitis C virus infection. Chronic viral hepatitis C
Conditions
Interventions
Intervention: Interferon therapy plus fluoroquinolone.
Treatment - Drugs
Intervention: Interferon therapy plus fluoroquinolone
Sponsors
Higher Education Commission, Pakistan
Eligibility
Sex/Gender
All
Age
25 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: •Patient on IFN treatment who have not shown two-log reduction in their HCV load for 3 months •HCV-RNA positive •Infection with HCV genotype 3a •Chronic hepatitis diagnosed by liver ultrasound •Pre-cirrhotic, as determined by liver ultrasound •Informed consent to participate in the study Exclusion criteria: •Known hypersensitivity to fluoroquinolones •Infection with HCV genotype other than 3a •Pregnant females •Concurrent hepatitis B or HIV infection •Carcinomatous changes on liver biopsy evident in liver ultrasound •History of alcohol or intravenous drug abuse •Disinclination to informed consent
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Viral load. Timepoint: 3 months post drug treatment. Method of measurement: Quantitative Real Time PCR for viral RNA. | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver function test and Complete Blood Count. Timepoint: Weekly throughout the drug treatment. Method of measurement: Clinical laboratory using automated testing units and microscopy. | — |
Countries
Pakistan
Contacts
Public ContactSyed Hani Abidi
Aga Khan University
Outcome results
None listed