Probiotic supplementation in infertile men

Evaluation The Efficacy Of Probiotic Supplement On Sperm Parameters, Sex Hormones, Oxidative Stress Index and Inflammatory Factors In Men With Idiopathic Infertility: Randomized Double Blind Clinical Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141025019669N7

Enrollment

Registered

2018-01-26

Start date

2017-11-22

Completion date

Unknown

Last updated

2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthenospermia. Male infertility

Interventions

Intervention 1: Intervention group: Probitic, 500 mg per daily. Intervention 2: Control group: Plasebo.

Eligibility

Sex/Gender

Male

Age

20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Willing to participate in the study No conception after 12 months intercourse without any contraception) Idiopathic asthenospermia according to World Health Organization criteria Normal levels of gonadotropins, testosterone and prolactin of serum

Exclusion criteria

Exclusion criteria: Any infection in genitourinary (GU) tract Any anatomical abnormality in GU tract Contact with pesticides, heavy metals and solvents Consumption of antioxidant supplements during last 3 months

Design outcomes

Primary

Measure	Time frame
Sperm parameters. Timepoint: Before the intervention and after the intervention. Method of measurement: Spermatogram.;Inflammatory factors. Timepoint: Before the intervention and after the intervention. Method of measurement: Eliza.;Antioxidant indices. Timepoint: Before intervention and after intervention. Method of measurement: Eliza.;Sex hormones. Timepoint: Before intervention and after intervention. Method of measurement: Eliza.;Sleep quality. Timepoint: Before intervention and after intervention. Method of measurement: Petersburg’s sleep quality questionnaire.	—

Measure

Time frame

Sperm parameters. Timepoint: Before the intervention and after the intervention. Method of measurement: Spermatogram.;Inflammatory factors. Timepoint: Before the intervention and after the intervention. Method of measurement: Eliza.;Antioxidant indices. Timepoint: Before intervention and after intervention. Method of measurement: Eliza.;Sex hormones. Timepoint: Before intervention and after intervention. Method of measurement: Eliza.;Sleep quality. Timepoint: Before intervention and after intervention. Method of measurement: Petersburg’s sleep quality questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Bizhan Helli

Ahvaz University of Medical Sciences

bizhanhelli@yahoo.com+98 61 1373 8254

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 17, 2026