The effect of gallic acid supplementation in patients with major depression

The effect of oral gallic acid supplementation on antioxidant status in people with major depression

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141025019669N17

Enrollment

Registered

2021-03-22

Start date

2021-04-04

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major depressive episode. Major depressive disorder, single episode

Interventions

Intervention 1: Intervention group: Gallic acid, a capsule 200 mg per daily for two months, Manufacturer: Supplement Spot. Intervention 2: Control group: A daily placebo capsule containing wheat flour

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Men and women with Major Depressive Willingness to work Age 18- 55 Non-modification of treatment and medications for at least the past 2 months

Exclusion criteria

Exclusion criteria: Pregnancy and breastfeeding Patients with severe renal and hepatic dysfunction Alcohol consumption

Design outcomes

Primary

Measure	Time frame
Severity of depression. Timepoint: Before the intervention and after the intervention. Method of measurement: Hamilton Rating Scale.	—

Secondary

Measure	Time frame
Total antioxidant capacity. Timepoint: Before the intervention and after the intervention. Method of measurement: Eliza.;Malondialdehyde. Timepoint: Before the intervention and after the intervention. Method of measurement: Eliza.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactGholamreza Houshmand

Mazandaran University of Medical Sciences

g.houshmand@mazums.ac.ir+98 11 3354 3081

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026