Oleoylethanolamide supplementation effect in patients with prediabetes

Evaluation of the effect of oral oleoylethanolamide (OEA) supplement on glycemic indexes, insulin resistance and C-reactive protein in pre-diabetic patients: A double-blind controlled clinical trial with placebo

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141025019669N16

Enrollment

Registered

2021-03-10

Start date

2021-02-27

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prediabetes. Impaired glucose tolerance (oral)

Interventions

Intervention 1: Intervention group: Oleoylethanolamide, a capsule 125 mg per daily for two months, Manufacturer: Supplement Spot. Intervention 2: Control group: A daily placebo capsule containing whea

Eligibility

Sex/Gender

All

Age

24 Years to 55 Years

Inclusion criteria

Inclusion criteria: Men and women with prediabetes Willingness to work Age 25- 55 Non-modification of treatment and medications for at least the past 2 months Moderate physical activity

Exclusion criteria

Exclusion criteria: Pregnancy and breastfeeding Patients with severe renal and hepatic dysfunction Alcohol consumption

Design outcomes

Primary

Measure	Time frame
Fasting blood sugar. Timepoint: Before the intervention and after the intervention. Method of measurement: Eliza.;2 hours sugar. Timepoint: Before the intervention and after the intervention. Method of measurement: Eliza.;Insulin resistance. Timepoint: Before the intervention and after the intervention. Method of measurement: Using the formula.;Glycosylated hemoglobin. Timepoint: Before the intervention and after the intervention. Method of measurement: Eliza.;Inflammatory factor. Timepoint: Before the intervention and after the intervention. Method of measurement: Eliza.	—

Measure

Time frame

Fasting blood sugar. Timepoint: Before the intervention and after the intervention. Method of measurement: Eliza.;2 hours sugar. Timepoint: Before the intervention and after the intervention. Method of measurement: Eliza.;Insulin resistance. Timepoint: Before the intervention and after the intervention. Method of measurement: Using the formula.;Glycosylated hemoglobin. Timepoint: Before the intervention and after the intervention. Method of measurement: Eliza.;Inflammatory factor. Timepoint: Before the intervention and after the intervention. Method of measurement: Eliza.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHossein Khadem Haghighian

Qazvin University of Medical Sciences

khademnut@yahoo.com+98 28 3333 6001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 12, 2026