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A Comparison of Opioid –Free Anesthesia with Conventional Balanced Anesthesia in Reducing Post-Operative Nausea and Vomiting in patients undergoing transurethral resection of bladder tumor or transurethral resection of prostate surgery: An RCT study.

A Comparison of Opioid –Free Anesthesia with Conventional Balanced Anesthesia in Reducing Post-Operative Nausea and Vomiting in patients undergoing transurethral resection of bladder tumor or transurethral resection of prostate surgery: An RCT study.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2014102319640N1
Enrollment
156
Registered
2015-12-26
Start date
2016-01-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Hyperplasia of prostate. Condition 2: Malignant neoplasm of bladder. Hyperplasia of prostate Malignant neoplasm of bladder

Interventions

Intervention 1: Intervention (study) Group: Opioid-free anesthesia: We will not use any opioid including fentanyl during the anesthesia in this group. The anesthesia will be administered by following
Treatment - Drugs
Intervention (study) Group: Opioid-free anesthesia: We will not use any opioid including fentanyl during the anesthesia in this group. The anesthesia will be administered by following drugs, includin
Control Group: conventional (balanced) anesthesia: The anesthesia will be administered by following drugs, including: Midazolam 2 mg IV, Fentanyl 3 micg/kg, Thiopental 5 mg/kg IV, Atracurium 0.5 mg/kg

Sponsors

Vice chancellor for research, Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
17 Years to 75 Years

Inclusion criteria

Inclusion criteria: Exclusion criteria: Age 75; Usage of High doses of opioids before the operation; Patients with allergy to any medication used in the study; Patients with hypertension or ischemic heart disease even if perfectly controlled; Patients who have not completed their "Nothing Per Os" time; Patients who need to get any corticosteroids or any pro-kinetic medication; Patients with history of snoring or sleep apnea Inclusion criteria: Opioid naïf patients; Patients with American Society of Anesthesiologists class I – III.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Post-Operative Nausea and Vomiting. Timepoint: The first day after the surgery. Method of measurement: Categorical rating scale.—

Secondary

MeasureTime frame
Pain intensity. Timepoint: The first day after the surgery. Method of measurement: Numeric rating scale.—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Hossein Majedi

Imam Khomeini Hospital, Tehran university of medical sciences

hossein_majedi@yahoo.com+98 21 2234 4084

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026