Effect of intravenous magnesium sulfate versus placebo on postoperative pain and urethral catheter discomforts in patients undergo transurethral ureterolithotripsy

Effect of intravenous magnesium sulfate versus placebo on postoperative pain and urethral catheter discomforts in patients undergo transurethral ureterolithotripsy: a double blinded randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201410229014N45

Enrollment

Registered

2014-10-28

Start date

1992-06-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

kidney stone. Calculus of kidney

Interventions

Intervention 1: Intravenous infusion of 25 mg/kg magnesium sulfate in 500 ml ringer serum 5 min before spinal anesthesia plus intravenous infusion of 25 mg/kg magnesium sulfate in 1000 ml ringer serum

Treatment - Drugs

Placebo

Intravenous infusion of 25 mg/kg magnesium sulfate in 500 ml ringer serum 5 min before spinal anesthesia plus intravenous infusion of 25 mg/kg magnesium sulfate in 1000 ml ringer serum after surgery t

Intravenous infusion of 500 ml normal saline 5 min before spinal anesthesia plus intravenous infusion of 500 ml normal saline after surgery twice with an 8-hour interval.

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: (a) candidate for transurethral ureterolithotripsy; (b) age of 18 to 70 years; (b) serum magnesium less than 2.5 mg/dl. Exclusion criteria: (a) transurethral ureterolithotripsy in combination with other procedure; (b) incomplete discharge of stone; (c) general anesthesia; (d) having renal disease.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Severity of back pain. Timepoint: 6, 12, and 18 hours after surgery. Method of measurement: using Numerical Rating Scale.;Severity of flank pain. Timepoint: 6, 12, and 18 hours after surgery. Method of measurement: using Numerical Rating Scale.;Severity of abdominal pain. Timepoint: 6, 12, and 18 hours after surgery. Method of measurement: using Numerical Rating Scale.;Severity of urethral discomforts. Timepoint: 6, 12, and 18 hours after surgery. Method of measurement: using Numerical Rating Scale.	—

Measure

Time frame

Severity of back pain. Timepoint: 6, 12, and 18 hours after surgery. Method of measurement: using Numerical Rating Scale.;Severity of flank pain. Timepoint: 6, 12, and 18 hours after surgery. Method of measurement: using Numerical Rating Scale.;Severity of abdominal pain. Timepoint: 6, 12, and 18 hours after surgery. Method of measurement: using Numerical Rating Scale.;Severity of urethral discomforts. Timepoint: 6, 12, and 18 hours after surgery. Method of measurement: using Numerical Rating Scale.

—

Secondary

Measure	Time frame
Number of analgesic used. Timepoint: during 24 hours after surgery. Method of measurement: Medical record.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZandra Golparvar

Shahid Beheshti Hospital

dr_golparvar_65@yahoo.com+98 81 3838 0705

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026