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Evaluating the effect of Colchicine & Probiotics mixture on Colon Transient Time

A randomized double blind clinical trial evaluating the effect of Colchicine & Probiotics mixture on Colon Transient Time in patient with idiopathic constipation

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2014102119616N1
Enrollment
50
Registered
2014-11-26
Start date
2014-04-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Idiopatic Constipation. Constipation

Interventions

Intervention 1: The first group get 0.6 mg of colchicine per day for 4 weeks. Intervention 2: The second group takes a 500mg probiotic capsule per day for 4 weeks. Each capsule is composed of the foll
2- Lactobacillus acidophilus 2 x109 CFU/g
3- Lactobacillus rhamnosus 1.5 x109 CFU/g
4- Lactobacillus bulgaricus 2 x 109CFU/g
5-Bifidobacterium breve 2 x 109CFU/g
6- Bifidobacterium longum 7 x 109CFU/g
7- Streptococcus thermophilus 1.5 x 109 CFU/g.
Treatment - Drugs
The first group get 0.6 mg of colchicine per day for 4 weeks
The second group takes a 500mg probiotic capsule per day for 4 weeks. Each capsule is composed of the following materials: 1- Lactobacillus casei 7 x 109 CFU/g

Sponsors

Ilam University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion criteria: all patients who refer to the internal medicine clinic with complaints of constipation and have ROME III criteria. Exclusion criteria: uncooperative patients to enter the study and evaluation of colonic transient time; patients who normal colonic transit time or in the recto sigmoid part; patients who have secondary causes of constipation; patients who don't complete treatment.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Colon transit time. Timepoint: Before and after treatment. Method of measurement: 5 capsules containing ten markers.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMilad Rashidbeygi

Student Committee Research, Ilam University of Medical Sciences

miladrashidbeygi@yahoo.com+98 84 1223 5700

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026