Corneal ulcers. Corneal ulcer
Conditions
Interventions
Intervention 1: We do collagen cross linkage at time of addmision in case group .
We instiled Riboflavin(1%) drop every five minute till 30 minute then ultraviolet radiation ( 400nm ) for 30 minute
Treatment - Surgery
Treatment - Drugs
We do collagen cross linkage at time of addmision in case group .
We instiled Riboflavin(1%) drop every five minute till 30 minute then ultraviolet radiation ( 400nm ) for 30 minute and during this
In controlled group we start fortified cefazolin ( loomg/ml ) and fortified gentamacin ( 14 mg/ml ) every 30 minute and according to clinical response and result of culture and smear we change the the
Sponsors
Shiraz Univercity of Medical Seiences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 32 patients with corneal ulcer will be selected 16 cases and 16 control group. The study will be restricted to patients who will refer to Khalili hospital; moderate corneal ulcers Patients that will have any kind of corneal perforation; those with a corneal descematocele;patients with collagen vascular disease and immunocompromised patients;and patients who will need any kind of emergency keratoplasty will be excluded from our study
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Corneal ulcers. Timepoint: Before the intervention, and daily. Method of measurement: Response to treatment according to improvement of ulcer with measurment of epithelialization ( milimeter ) and improvement of stromal infiltration. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of non- healing corneal ulcers. Timepoint: Daily. Method of measurement: No improvement in corneal epithelialization and stromal infiltrations. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShahram Bamdad
Shiraz Univercity of Medical Seiences
Outcome results
None listed