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Comparison of analgesic and sedative effect of combined propofol plus fentanyl and propofol plus ketamine

Comparison of analgesic and sedative effect of combined propofol plus fentanyl and propofol plus ketamine in patients undergoing endoscopic retrograde of cholangiopancreatography

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT201410187752N6
Enrollment
60
Registered
2014-12-09
Start date
2014-03-20
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sedation. Other and unspecified general anaesthetics

Interventions

Intervention 1: The Intervention group receives 1 mg midazolam and0.5 mg/kg ketamine before ERCP and 0.5 mg / kg propofol as a rescue bolus dose then followed by 75microgram / kg / min infusion. Int
Treatment - Drugs
The Intervention group receives 1 mg midazolam and0.5 mg/kg ketamine before ERCP and 0.5 mg / kg propofol as a rescue bolus dose then followed by 75microgram / kg / min infusion
the control group receives midazolam 1 mg and fentanyl 50 to 100 micrograms before ERCP and 0.5 mg / kg propofol as a rescue bolus dose and then followed by 75microgram / kg / min infusion

Sponsors

Vice-chancellor of research of Babol University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age 18-80 years; ASA class = 3 Exclusion criteria: age 80 years; Heart disease (arrhythmias, Aortic Stenosis, Ischemic Heart Disease,Heart failure) ; liver disease (Child-Pugh classification C); drug addiction.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Sedation. Timepoint: Every 2 minutes till 10 minutes and then every 5 minutes till 1 houre. Method of measurement: Ramsay Sedation Scale.;Pain. Timepoint: Every 2 minutes till 10 minutes and then every 5 minutes till 1 houre. Method of measurement: Visual Analoge Scale.

Secondary

MeasureTime frame
Blood pressure. Timepoint: Every 2 minutes till 10 minutes and then every 5 minutes till 1 houre. Method of measurement: sphygmomanometer.;Respiratory Rate. Timepoint: Every 2 minutes till 10 minutes and then every 5 minutes till 1 houre. Method of measurement: observation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmri Maleh Parviz

Vice-chancellor of research of Babol University of Medical Sciences

pamrimaleh@yahoo.com+98 11 1223 8296

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026