Effects of regenerative agents injection in knee osteoarthrosis

A double blinded clinical trial for evaluation of PRP(Platelet riched plasma) with prolotherapy intraarticular injection on pain score and range of motion in knee osteoarthritis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014101810599N2

Enrollment

Registered

2015-06-27

Start date

2014-10-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthrosis. Primary unilateral knee arthrosis

Interventions

Intervention 1: In intervention group platelet riched plasma will be injected intra-articular to the knee one time. ?For preparing this product Biojel kit (USA) will be used which gives 7-10 CC plasm

Treatment - Surgery

In intervention group platelet riched plasma will be injected intra-articular to the knee one time. ?For preparing this product Biojel kit (USA) will be used which gives 7-10 CC plasma after two stag

In control group dextrose will be injected intra-articular to the knee one time. 7 cc dextrose with concentration of 25%(Ghazi co, Iran) will be used for this purpose.

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Knee osteoarthritis stage I-III according to American Rheumatologist society criteria or radiologic criteria I-III according to Kalgreen-Lawrence criteria, 40-70 years age. Exclusion criteria: addiction to opioids or alcohol, history of rheumatoid arthritis or any rheumatologic disease, hemophilia

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain score. Timepoint: Before performing the intervention (0) and 1, 4 & 8 weeks after performing the intervention. Method of measurement: Visual analogue scale with specialized ruler and recording in questionnaire.;Knee range of motion. Timepoint: Before performing the intervention (0) and 1, 4 & 8 weeks after performing the intervention. Method of measurement: Using goniometer and recording in questionnaire.	—

Measure

Time frame

Pain score. Timepoint: Before performing the intervention (0) and 1, 4 & 8 weeks after performing the intervention. Method of measurement: Visual analogue scale with specialized ruler and recording in questionnaire.;Knee range of motion. Timepoint: Before performing the intervention (0) and 1, 4 & 8 weeks after performing the intervention. Method of measurement: Using goniometer and recording in questionnaire.

—

Secondary

Measure	Time frame
Pain killer number. Timepoint: Before performing the intervention (0) and 1, 4 & 8 weeks after performing the intervention. Method of measurement: number of pain killer usage and record in questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactPoupak Rahimzadeh

Iran University of Medical Sciences

poupak_rah@hotmail.com; p-rahimzadeh@tums.ac.ir+98 21 6435 2326

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026