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The effect of dexmedetomedine and clonidine on hemodynamics and postoperative pain of laparoscopic cholecystectomy

Comparison Effects of Dexmedetomidine and Clonidine as Premedication in Perioperative Hemodynamic Stability and Post-op Pain in Laparoscopic Cholecystectomy

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20141009019470N96
Enrollment
135
Registered
2020-01-20
Start date
2020-02-04
Completion date
Unknown
Last updated
2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparoscopic Cholecystectomy. Calculus of bile duct with chronic cholecystitis without obstruction

Interventions

Intervention 1: Intervention group: Dexmedetomidine infusion (Hospira, INC, Lake Forest, IL 60045 USA) is initiated 5 min before surgical incision at a dose of 0.2 µg / kg.One dose of clonidine simila

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients Candidate for Laparoscopic Cholecystectomy Surgery Age 18-65 years Class (ASA) I, II

Exclusion criteria

Exclusion criteria: Communication problem Hypertension Heart disease Anemia Liver and Kidney Diseases Hormonal diseases Concurrent acute or chronic pain Gastrointestinal problems Sexual disorders CNS disorders Respiratory allergy Diabetes Pregnancy Duration of surgery more than 120 minutes

Design outcomes

Secondary

MeasureTime frame
Nausea and Vomiting. Timepoint: At the onset of recovery and thereafter every 15 minutes until recovery discharge . Method of measurement: Nausea and vomiting grading scale.;Sedation. Timepoint: At the onset of recovery and thereafter every 15 minutes until recovery discharge. Method of measurement: Ramsay sedation scale.

Primary

MeasureTime frame
Blood Pressure. Timepoint: Before induction, after induction, at the onset of surgery and every 5 minutes until the end of the surgery. Method of measurement: Monitoring.;Pain. Timepoint: At the onset of recovery and thereafter every 15 minutes until recovery discharge . Method of measurement: Visual Analogue Scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Rafati

Shiraz University of Medical Sciences

rafati.z@yahoo.com+98 71 3647 4270

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026