Coronary Artery Bypass Grafting Surgery.. Atherosclerotic heart disease of native coronary artery
Conditions
Interventions
Intervention 1: Intervention group: Patients received two oral capsules of melatonin 5 mg daily made by (Super Natural ,Canada)from four weeks prior to surgery and up to two days after surgery. Int
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients aged 40-75 years Patients who are undergoing elective Cardio pulmonary artery bypass grafting.
Exclusion criteria
Exclusion criteria: Acute recent Myocardial Infarction (less than 3 month) Aortic atheromatosis Renal dysfunction; Peripheral vascular disease; Pump time more than 90 min; Corticosteroid therapy since 1 month ago; infection less than 4 weeks ago; Breast feeding Pregnancy; Dementia; Psychiatric disorders Using Benzodiazepines and opioid; Alcohol abuse Hepatic insufficiency Non sinus ECG; Concomitant cardiac surgery; Anticoagulation therapy with warfarin ASA higher than 3 Ejection Fraction less than 45% Severe pulmonary disease Cerebrovascular disease Immunologic disorders Re-operation Emergency operation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function. Timepoint: 4 weeks before surgery,2 days after surgery and 6 weeks after melatonin administration. Method of measurement: Cognitive function Test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactKambiz Zohori
Shiraz University of Medical Sciences
Outcome results
None listed