Comparison the Analgesic Effects of Acetaminophen, Meperidine, and their Combination in Elective Cesarean Section Surgeries under Spinal Anesthesia

Comparison the Analgesic Effects of Acetaminophen, Meperidine, and their Combination on Postoperative Pain Management in Elective Cesarean Section Surgeries under Spinal Anesthesia

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20141009019470N75

Enrollment

120

Registered

2018-05-04

Start date

2018-01-05

Completion date

Unknown

Last updated

2018-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elective Cesarean Section. Encounter for cesarean delivery without indication

Interventions

Intervention 1: Intervention group: 40 patients received 15mg/kg iv. acetaminophen (diluted in 100 cc normal saline solution). Intervention 2: Intervention group: 40 patients received 0.5mg/kg iv mepe

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: full-term pregnant women aged 18 to 40 years old American Society of anesthesiologists physical status classification I(ASA I) undergoing elective cesarean section under spinal anesthesia

Exclusion criteria

Exclusion criteria: contraindications for meperidine or acetaminophen history of alcoholism drug abuse convulsion migraine dicopathy hepatitis renal failure cardiovascular or pulmonary diseases preeclampsia or eclampsia, hypertension diabetes, gravidity more than 3 surgery more than 90-minute failed or partial S/A, Intrauterine Growth Restriction (IUGR), multiple pregnancies fetal distress

Design outcomes

Primary

Measure	Time frame
Pain score. Timepoint: At 1, 2, 4, 6, 12, and 24 h after the surgery. Method of measurement: Visual Analogue Scale (VAS).;Nausea and vomiting,. Timepoint: At 1, 2, 4, 6, 12, and 24 h after the surgery. Method of measurement: Observation.;Shivering. Timepoint: At 1, 2, 4, 6, 12, and 24 h after the surgery. Method of measurement: Observation.;Headache. Timepoint: At 1, 2, 4, 6, 12, and 24 h after the surgery. Method of measurement: Observation.	—

Measure

Time frame

Pain score. Timepoint: At 1, 2, 4, 6, 12, and 24 h after the surgery. Method of measurement: Visual Analogue Scale (VAS).;Nausea and vomiting,. Timepoint: At 1, 2, 4, 6, 12, and 24 h after the surgery. Method of measurement: Observation.;Shivering. Timepoint: At 1, 2, 4, 6, 12, and 24 h after the surgery. Method of measurement: Observation.;Headache. Timepoint: At 1, 2, 4, 6, 12, and 24 h after the surgery. Method of measurement: Observation.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactLaleh Dehghanpishe

Shiraz University of Medical Sciences

lalehdehghan@yahoo.com+98 71 3628 1460

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026