Coronary Artery Bypass Surgery. Atherosclerotic heart disease of native coronary artery
Conditions
Interventions
Intervention 1: Intervention group: Patients in the placebo group received placebo every night two weeks before the operation. Intervention 2: Control group:patients in the placebo group received plac
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients who are candidate for elective CABG with age between 40-75 years old and ASA class <III; pump time less than 90 min; graft number between 2 to 6.
Exclusion criteria
Exclusion criteria: pregnancy and breast feeding; local or systemic infection; hyper sensitivity; redo surgery; surgery during last 6 months; collagen vascular disease; immunosuppressive disease; heart failure with ejection fraction less than 35%; recent cardiovascular event; un controlled HTN; renal failure; liver failure; alcohol abuser; malignancy; simultaneously valvular heart surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum level of Inflammatory cytokines. Timepoint: Two weeks before administration of melatonin, in the operating room before induction of anesthesia, 6 hours after declamping in the ICU and 48 hours after off pump. Method of measurement: venous blood samples. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMarzieh Ghasemi
Shiraz University of Medical Sciences
Outcome results
None listed